While Tom's very good at science, his brother is absolutely hopeless.
汤姆很擅长理科，而他的兄弟绝对是不可救药。
This case is hopeless and he knows it.
这个案子毫无希望，这一点他是清楚的。
He's a hopeless case.
他是无可救药了。
I'm hopeless at science.
我对理科一窍不通。
Our cat is hopeless at catching mice.
我们的猫绝对捉不到老鼠。
She felt lonely and hopeless.
她感到孤独绝望。