There comes a point where you give up.
现在你该放弃了。
I give up ─ tell me the answer.
我放弃了，把答案告诉我吧。
She knew from past experience that Ann would not give up easily.
她凭以往的经验知道安是不会轻易放弃的。
He suffered a serious injury that obliged him to give up work.
他受伤严重，不得已只好放弃工作。
He's trying to give up smoking.
他正设法戒烟。